Reduced graphene oxide‐based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy | Zendy

Hu Yanfang | Zendy; He Liang | Zendy; Ma Weiqian | Zendy; Chen Li | Zendy

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Reduced graphene oxide‐based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy

Author(s) -

Hu Yanfang,

He Liang,

Ma Weiqian,

Chen Li

Publication year - 2018

Publication title -

polymer international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.592

H-Index - 105

eISSN - 1097-0126

pISSN - 0959-8103

DOI - 10.1002/pi.5689

Subject(s) - bortezomib , graphene , photothermal therapy , drug delivery , drug , chemotherapy , pharmacology , nanotechnology , materials science , medicine , multiple myeloma

In cancer treatment, it still is a curial challenge to enhance therapeutic efficacy and reduce side effects. A novel reduced graphene oxide‐based nanoplatform (rGO/PDex) has been constructed to deliver an anticancer drug, bortezomib (BTZ), for photo‐chemotherapy. The structure and properties of the nanoplatform were characterized. The obtained data strongly indicated that rGO/PDex had enhanced stability. Further, folic acid was introduced and the resulting rGO/PDexF nanoplatform exhibited improved cellular uptake due to the active targeting effect. The anticancer drug BTZ could be effectively encapsulated into the rGO‐based nanoplatform and be released in a controlled manner. In vitro experiments demonstrated that BTZ‐loaded rGO‐based nanoparticles displayed enhanced therapeutic efficacy compared with the single chemotherapy, indicating the great potential of rGO‐based nanoparticles for cancer treatments. © 2018 Society of Chemical Industry

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