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Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study
Author(s) -
Wojtczak Edyta,
Gadzinowski Mariusz,
Makowski Tomasz,
Maresz Katarzyna,
Kubisa Przemysław,
Bednarek Melania,
Pluta Mirosław
Publication year - 2018
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5674
Subject(s) - ethylene glycol , polymer , copolymer , chemical engineering , drug delivery , controlled release , x ray photoelectron spectroscopy , materials science , kinetics , polymer chemistry , chemistry , nuclear chemistry , organic chemistry , nanotechnology , physics , quantum mechanics , engineering
Among different drug‐containing formulations prepared from biodegradable polymers, those based on polylactide (PLA) (usually block copolymers with poly(ethylene glycol)) are the most frequently developed and improved. A new easy method of such drug delivery system preparation with the application of PLA stereocomplexation is presented. The encapsulation of hydrophobic vitamins such as D 3 , E and A by spontaneous precipitation of microparticles with an average diameter of 1–2 µm led to a loading of about 10 wt% and an encapsulation efficiency in the range 27%–45% when a vitamin:PLA weight ratio of 3:10 was applied. SEM, TEM, X‐ray photoelectron spectroscopy and nitrogen absorption analysis of neat and vitamin‐loaded microparticles indicate a porous structure of the microparticles and confirm the presence of vitamins inside with an enriched surface layer. The release of vitamins into a phosphate buffer (pH 7.4) at 37 °C takes place at a low rate according to almost zero‐order kinetics (35%–60% of vitamin over 4 weeks). © 2018 Society of Chemical Industry