Premium
Thermo‐ and glucose‐sensitive microgels with improved salt tolerance for controlled insulin release in a physiological environment
Author(s) -
Gu Shiling,
Yang Liu,
Li Shirui,
Yang Junjiao,
Zhang Bo,
Yang Jing
Publication year - 2018
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5634
Subject(s) - ethylene glycol , ionic strength , phenylboronic acid , salt (chemistry) , peg ratio , colloid , drug delivery , ethyl acrylate , chemical engineering , copolymer , acrylate , nanoparticle , emulsion , materials science , precipitation , chemistry , polymer chemistry , chromatography , nanotechnology , organic chemistry , polymer , catalysis , aqueous solution , physics , finance , meteorology , engineering , economics
The response to temperature and glucose, high salt tolerance and self‐regulated drug delivery are simultaneously probable by applying a multifunctional microgel in a rational design by a colloid chemistry method. Such smart microgels were fabricated with thermoresponsive N ‐isopropylacrylamide, glucose‐sensitive (2‐phenylboronic esters‐1,3‐dioxane‐5‐ethyl)methyl acrylate (PBDEMA) and water‐soluble crosslinker poly(ethylene glycol) diacrylate through a precipitation emulsion method. These colloidal nanoparticles exhibited PBDEMA‐composition‐dependent responsive behavior with changing temperature and ionic strength. Amongst them, the microgel with 20.7 mol% PBDEMA with a narrow size distribution is suitable for diabetes treatment because it can adapt to the surrounding medium of different glucose concentrations over a clinically relevant range (0–2.0 mg mL −1 ), control the release of preloaded insulin and is highly stable under normal physiological conditions. Preliminary experiments suggest these highly stable microgels have the potential to be used for self‐regulated therapy and monitoring the response to treatment. © 2018 Society of Chemical Industry