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Application of minimally invasive injectable conductive hydrogels as stimulating scaffolds for myocardial tissue engineering
Author(s) -
Ketabat Farinaz,
Khorshidi Sajedeh,
Karkhaneh Akbar
Publication year - 2018
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5599
Subject(s) - self healing hydrogels , tissue engineering , materials science , biomedical engineering , extracellular matrix , regeneration (biology) , electrical conductor , conductive polymer , polymer , nanotechnology , chemistry , polymer chemistry , composite material , medicine , biochemistry , biology , microbiology and biotechnology
So far, several methods for myocardial tissue engineering have been developed to regenerate myocardium and even create contractile heart muscles. Among these approaches, hydrogel based methods have attracted much attention due to their ability to mimic the architecture of native extracellular matrix. Injectable hydrogels are a specific class of hydrogels which can be formed in situ by physical and/or chemical crosslinking. Generally, using these hydrogels is more advantageous because they are minimally (less) invasive in comparison with open surgery. Moreover, with respect to the fact that ‘myocardium is a conductive tissue’, utilization of conductive polymers for myocardial tissue engineering has demonstrated promising results. Both the injectable hydrogels and conductive polymers have some merits and demerits, but studies show that using a combination of them has prominently enhanced regeneration of the myocardium. In this review, the focus is on injectable hydrogels, conductive polymers and injectable conductive hydrogels for myocardial tissue engineering. © 2018 Society of Chemical Industry