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Dynamic covalent polymer hydrogels and organogels crosslinked through acylhydrazone bonds: synthesis, characterization and applications
Author(s) -
Apostolides Demetris E,
Patrickios Costas S
Publication year - 2018
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5554
Subject(s) - covalent bond , self healing hydrogels , polymer , biomolecule , materials science , polymer chemistry , characterization (materials science) , network covalent bonding , chemical engineering , chemistry , polymer science , nanotechnology , organic chemistry , engineering
We review recent literature on the rapidly expanding field of dynamic covalent polymer networks (DCPNs) crosslinked with acylhydrazone bonds, classified according to their structural perfection: randomly crosslinked and model DCPNs. The dynamic covalent acylhydrazone bond is greatly sensitive to environmental conditions, pH in particular, and is characterized by great stability under neutral and mildly alkaline conditions, and instability under acidic conditions. The dynamic nature of this bond endows DCPNs crosslinked with acylhydrazone bonds with self‐healing ability, reversibility and injectability. The last property enables the in vivo site‐specific delivery of drugs, biomolecules or cells that have been loaded into DCPN hydrogels. © 2018 Society of Chemical Industry