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Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier
Author(s) -
Zhang Yucheng,
Yi Meijun,
Bao Yi,
Zhang Shiping
Publication year - 2018
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5482
Subject(s) - phosphorylcholine , micelle , copolymer , hela , atom transfer radical polymerization , materials science , cytotoxicity , polymer chemistry , polymer , aqueous solution , organic chemistry , chemistry , in vitro , biochemistry
A series of copolymers of poly(2‐methacryloyloxyethyl phosphorylcholine)‐ b ‐poly(butylene succinate)‐ b ‐poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC‐ b ‐PBS‐ b ‐PMPC) were synthesized by atom transfer radical polymerization. The structure of the polymers was characterized by 1 H NMR and infrared spectroscopy, and their thermal properties were described using TGA and DSC. In aqueous solutions, the PMPC‐ b ‐PBS‐ b ‐PMPC could form micelles with sizes ranging from 108 to 170 nm. In vitro release studies showed that acidic media and a longer PMPC chain benefited doxorubicin (DOX) release. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assays indicated that the micelles had low cytotoxicity to HeLa and L929 cells. DOX‐loaded micelles exhibited high cytotoxicity to HeLa cells. Flow cytometry results demonstrated that DOX‐loaded micelles could be internalized by HeLa cells. The in vitro phagocytosis results showed 3.9‐fold and 5.5‐fold reductions compared with poly(lactic acid) (PLA) nanoparticles and PDS55 micelles. These results demonstrate that PMPC‐ b ‐PBS‐ b ‐PMPC block copolymer micelles have great promise for cancer therapy. © 2017 Society of Chemical Industry