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Synthesis of highly swellable hydrogels of water‐soluble carboxymethyl chitosan and poly(ethylene glycol)
Author(s) -
Gámiz González María Amparo,
Edlund Ulrica,
Vidaurre Ana,
Gómez Ribelles José Luís
Publication year - 2017
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5424
Subject(s) - self healing hydrogels , diglycidyl ether , chitosan , ethylene glycol , swelling , materials science , polymer chemistry , peg ratio , chemical engineering , dynamic mechanical analysis , swelling capacity , polymer , composite material , epoxy , bisphenol a , finance , economics , engineering
Abstract Highly swellable hydrogels were produced by crosslinking of high molecular weight carboxymethylated chitosan (CmCHT) with poly(ethylene glycol) (PEG) oligomers. The hydrogel swelling capacity could be controlled via the crosslinking density and ranged from 900% to 5600%. The hydrogels showed good homogeneity with a high interconnected porosity in the swollen state and with nanodomains rich in CmCHT and others rich in PEG diglycidyl ether. Oscillatory frequency sweep analysis showed a storage modulus of 27 kPa for the hydrogel with the highest crosslinking density, which together with the exhibited enzyme degradability with lysozyme at 59 days indicate that these hydrogels have potential use in delivery systems or soft tissue regeneration. © 2017 Society of Chemical Industry