Premium
Molecularly imprinted polymers by phase inversion technique for the selective recognition of saccharides of biomedical interest in aqueous solutions
Author(s) -
Barbani Niccoletta,
Rosellini Elisabetta,
Donati Marco,
Costantino Paolo,
Cristallini Caterina,
Ciardelli Gianluca
Publication year - 2017
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5334
Subject(s) - phase inversion , selectivity , molecularly imprinted polymer , molecular imprinting , chemistry , ethylene , polymer , copolymer , molecule , maltose , aqueous solution , molecular recognition , combinatorial chemistry , chemical engineering , polymer chemistry , organic chemistry , membrane , catalysis , biochemistry , engineering , enzyme
The purpose of this work was the preparation and characterization of polymeric membranes for the selective recognition of saccharides using molecular imprinting technology associated with phase inversion. A system able to bind saccharides with high selectivity is particularly important in the pharmaceutical sector, since some of these compounds are constituents of molecules which can exert serious toxic effects even at very low concentrations. Two polymeric matrices were prepared using poly(ethylene‐ co ‐vinyl alcohol) copolymers, with an ethylene molar content of 32% and 44%, and were imprinted with two different saccharide molecules: maltose and 2‐keto‐3‐deoxy‐ d ‐manno‐octulosonate ( KDO ). Matrices imprinted against maltose and KDO showed an easy template extraction, high binding capability and satisfactory selectivity, particularly for the matrix with an ethylene molar content of 44%. © 2017 Society of Chemical Industry