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Synthesis of novel thermo‐ and redox‐sensitive polypeptide hydrogels
Author(s) -
Liu Lin,
Pei Yueting,
He Chaoliang,
Chen Li
Publication year - 2017
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5313
Subject(s) - self healing hydrogels , propargyl , copolymer , biocompatibility , polymer chemistry , redox , polymerization , click chemistry , peg ratio , materials science , aqueous solution , chemistry , polymer , organic chemistry , catalysis , finance , economics
Abstract Multi‐responsive hydrogels have recently received considerable attention for bioapplications. Here, novel temperature‐ and redox‐responsive polypetide hydrogels have been developed. Thermo‐sensitive hydrogels based on poly(ethyleneglycol)‐ block ‐poly(γ‐propargyl‐ l ‐glutamate) ( PEG‐PPLG ) were first synthesized by the ring opening polymerization of γ‐propargyl‐ l ‐glutamate N ‐carboxyanhydride ( PLG‐NCA ) with amino group terminated PEG monomethyl ether ( mPEG‐NH 2 ) as macroinitiator and were then functionalized via the ‘thiol‐yne’ click reaction between the propargyl pendents and the thiol‐containing 1‐propanethiol. The sol − gel phase transition of the obtained copolymer aqueous solution in response to temperature change was studied. The mass loss of the hydrogel in vitro was accelerated in the presence of H 2 O 2 , exhibiting a redox‐responsive property. Further, the methyl thiazolyl tetrazolium viability results revealed that this polypetide hydrogel has excellent biocompatibility, presenting potential applications in the biomedical field. © 2016 Society of Chemical Industry