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Polyhydroxyalkanoate‐based drug delivery systems
Author(s) -
Michalak Michał,
Kurcok Piotr,
Hakkarainen Minna
Publication year - 2017
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5282
Subject(s) - polyhydroxyalkanoates , biocompatibility , drug delivery , nanotechnology , drug , drug carrier , materials science , biochemical engineering , chemistry , pharmacology , medicine , organic chemistry , engineering , bacteria , biology , genetics
Microbial polyhydroxyalkanoates ( PHAs ) have been a subject of significant research interest in the past few decades. The recent development of novel functionalized PHAs has opened up new possibilities to combine the good biocompatibility of PHA ‐based drug delivery systems to, for example, improve drug loading and release properties, targeting or imaging functionalities. This mini‐review presents some recent scientific developments in the preparation of functionalized PHAs , PHA –drug and PHA –protein conjugates, multifunctional PHA nanoparticles and micelles as well as biosynthetic PHA particles for drug delivery. These developments in combination with the generally excellent biocompatibility of PHA materials are expected to further expand the interest in PHA materials for drug delivery and other therapeutic applications. © 2016 Society of Chemical Industry