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Tuning core hydrophobicity of spherical polymeric nanoconstructs for docetaxel delivery
Author(s) -
Di Mascolo Daniele,
Basnett Pooja,
Palange Anna Lisa,
Francardi Marco,
Roy Ipsita,
Decuzzi Paolo
Publication year - 2016
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5072
Subject(s) - plga , polymer , polyethylene glycol , drug delivery , bioavailability , docetaxel , controlled release , nanocarriers , materials science , chemistry , nanoparticle , nanotechnology , cytotoxicity , drug carrier , combinatorial chemistry , organic chemistry , pharmacology , cancer , in vitro , biochemistry , medicine
Poly(D,L‐lactide‐ co ‐glycolic) acid (PLGA) and poly(3‐hydroxybutyrate) (P(3HB)) are used for the formulation of Docetaxel‐loaded Spherical Polymeric Nanoconstructs (SPNs), modulating their pharmaco‐related properties but maintaining similar cytotoxic efficacy.

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