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Understanding the in situ crosslinked gelatin hydrogel
Author(s) -
Joy Jincy,
Gupta Amlan,
Jahnavi Sarvepalli,
Verma Rama S,
Ray Alok R,
Gupta Bhuvanesh
Publication year - 2016
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.5042
Subject(s) - gelatin , biocompatibility , self healing hydrogels , covalent bond , materials science , chemical engineering , in situ , polymer chemistry , phase (matter) , polymer science , nanotechnology , chemistry , organic chemistry , engineering , metallurgy
Abstract The present study focuses on an in‐depth investigation at the molecular level of in situ crosslinked gelatin hydrogel by oxidized carboxymethylcellulose ( OCMC ), intended for biomedical purposes. The crosslinking parameters, namely the crosslinking temperature, crosslinking time and the amount of crosslinker, were varied. The surface and bulk properties were investigated to construct a representative model postulating the interaction of gelatin and OCMC encompassing their physical and covalent linking which determines the properties of the hydrogel. It was inferred that covalent crosslinking facilitates the interfacial interaction between gelatin and OCMC which beyond 30% OCMC composition is impeded due to depletion: microdomain formation leading to phase separation. This study might enable the fabrication of tunable hydrogel with crosslinking parameters in accordance with its purpose. The preliminary biocompatibility studies of the hydrogel conclude that the crosslinked hydrogel generates favourable conditions for cells to adhere and proliferate showing potential for biomedical purposes. © 2015 Society of Chemical Industry