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Microencapsulation by coacervation of poly(lactide‐co‐glycolide)—II: Encapsulation of a dispersed aqueous phase
Author(s) -
Nihant N.,
Stassen S.,
Grandfils C.,
Jérǒme R.,
Teyssié Ph.
Publication year - 1993
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4990320210
Subject(s) - coacervate , materials science , chemical engineering , coating , polymer , aqueous solution , silicone oil , adsorption , aqueous two phase system , silicone , phase (matter) , polymer chemistry , nanotechnology , chemistry , organic chemistry , composite material , engineering
This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drug phase, and microcapsule solidification. This paper focuses on the physico‐chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium.