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Synthesis and evaluation of paramagnetic particulates as contrast agents for magnetic resonance imaging (MRI)
Author(s) -
Braybrook Julian H.,
Hall Laurance D.
Publication year - 1991
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4990260409
Subject(s) - paramagnetism , magnetic resonance imaging , nuclear magnetic resonance , materials science , relaxation (psychology) , spin–lattice relaxation , particulates , ion , chemistry , condensed matter physics , radiology , physics , organic chemistry , medicine
Formulations based on novel particulate ion‐exchange resins, containing a wide range of paramagnetic transition and rare‐earth metals bound to their surfaces, have been synthesised as potential contrast agents for the magnetic resonance imaging (MRI) of the gastro‐intestinal (GI) tract of man. They have been evaluated in terms of their effects upon the spin‐lattice ( R 1 ) and spin‐spin ( R 2 ) relaxation rates of the protons of water. Careful selection of the polymer, spacer‐arm, ligand and paramagnetic ion provides a means for subtle molecular tailoring. Further potential applications have been highlighted based on the observed properties of such formulations.