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Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry
Author(s) -
Sheng Weijuan,
Liu Teng,
Liu Shouxin,
Wang Qinqin,
Li Xuan,
Guang Naer
Publication year - 2015
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4934
Subject(s) - chemistry , polymer chemistry , self healing hydrogels , methacrylic acid , ethylene glycol , copolymer , methacrylate , radical polymerization , chain transfer , polymerization , click chemistry , poly(methacrylic acid) , atom transfer radical polymerization , aqueous solution , dynamic mechanical analysis , trifluoroacetic acid , polymer , organic chemistry
A novel temperature responsive copolymer, poly[2‐(2‐methoxyethoxy)ethyl methacrylate‐ co ‐oligo(ethylene glycol)methacrylate‐ co‐N ‐hydroxymethyl acrylamide] [P( MEO 2 MA ‐ co ‐ OEGMA ‐ co ‐ HMAM )], was synthesized by atom transfer radical polymerization. pH responsive poly(methacrylic acid) ( PMAA ) was synthesized by reversible addition‐fragmentation chain transfer polymerization. After the hydroxyl groups on P( MEO 2 MA ‐ co ‐ OEGMA ‐ co ‐ HMAM ) were transformed into azide groups and the carboxyl groups on PMAA were transformed into alkyne groups respectively, a novel temperature and pH responsive hydrogel was fabricated by click chemistry between the azide‐P( MEO 2 MA ‐ co ‐ OEGMA ‐ co ‐ HMAM ) and alkyne‐ PMAA in the presence of CuSO 4 and sodium ascorbate in aqueous solution. The rheological kinetics of gel formation demonstrated that gelation had commenced within 5 min at 25 °C, since then the storage modulus ( G ′) was higher than the loss modulus ( G ″). SEM images of hydrogel morphology and the swelling ratios of hydrogel at different temperatures and pH proved that the formed hydrogel had temperature and pH sensitivities. Bovine serum albumin was used as a model to evaluate the sustained release of the hydrogel; the results indicated that the hydrogel was a promising candidate for controlling protein drug delivery. © 2015 Society of Chemical Industry