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Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery
Author(s) -
Elakkiya Thangaraju,
Malarvizhi Govindaswamy,
Rajiv Sheeja,
Natarajan Thirupathur Srinivasan
Publication year - 2014
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4499
Subject(s) - fibroin , silk , bombyx mori , curcumin , nanofiber , materials science , fourier transform infrared spectroscopy , dynamic mechanical analysis , nuclear chemistry , electrospinning , chemical engineering , polymer chemistry , composite material , chemistry , polymer , biochemistry , gene , engineering
Silk fibroin from Bombyx mori silk cocoons was electrospun into silk nanofibers ( SNFs ). SEM images show that 9% w/v of SNFs was smooth and beadless having an average diameter in the range 30–150 nm. Curcumin (0.5–1.5 wt%) was incorporated into the silk fibroin solution and electrospun to obtain curcumin incorporated silk nanofibers ( CSNFs ) with diameters between 50 and 200 nm. The dispersion of curcumin in the SNFs was confirmed by TEM . The amorphous nature of curcumin upon incorporation into SNFs was confirmed by XRD . The functional groups of SNF and CSNF were confirmed by Fourier transform infrared spectroscopy. The SNFs and CSNFs were thermally stable up to ca 350 °C as evidenced by TGA . The glass transition temperature ( T g ) of SNFs (168 °C ) increased to 184 °C in the case of CSNFs as confirmed by DSC . The storage modulus, loss modulus and tan δ were determined by dynamic mechanical analysis. The percentages of porosity and water uptake of SNFs were 85% and 150%, respectively. The percentage in vitro cumulative release of curcumin at the end of the tenth day for 0.5, 1 and 1.5 wt% formulations was 82%, 84% and 80%, respectively. © 2013 Society of Chemical Industry