Premium
Synthesis and characterization of α‐amino acid‐containing polyester: poly[(ε‐caprolactone)‐ co ‐(serine lactone)]
Author(s) -
Wei Ying,
Li Xiaoyuan,
Jing Xiabin,
Chen Xuesi,
Huang Yubin
Publication year - 2013
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4334
Subject(s) - polyester , thermogravimetric analysis , dispersity , copolymer , caprolactone , differential scanning calorimetry , monomer , polymer chemistry , biocompatibility , materials science , serine , proton nmr , chemistry , nuclear chemistry , polymer , organic chemistry , physics , thermodynamics , enzyme
Novel polyesters, poly[(ε‐caprolactone)‐ co ‐( N ‐trityl‐ L ‐serine‐β‐lactone)]s, were prepared by copolymerizing ε‐caprolactone (CL) with N ‐trityl‐ L ‐serine‐β‐lactone (TSL) using ZnEt 2 as the catalyst. The number‐average molecular weights were determined which ranged from 2.7 × 10 4 to 4.9 × 10 4 Da with dispersity values ranging from 1.6 to 1.8. The structures of the copolymers were investigated by means of 1 H NMR, 13 C NMR and infrared spectroscopies, thermogravimetric analysis and differential scanning calorimetry. The results indicated that CL and TSL monomer units were randomly distributed within the copolymer backbone structures and the ratios of TSL to CL in the copolymers were close to those in the feeds. After removal of the trityl group under mild condition, a new polyester with side amino groups provided by serine units was obtained. L929 cell culturing test indicated good biocompatibility of the polyester with or without protective groups. © 2012 Society of Chemical Industry