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Synthesis and properties of a novel hyperbranched polyphosphoramidate using an A 2 + CB 2 approach
Author(s) -
Liu Yuhong,
Yan Ni,
Li Feng,
Chen Ping
Publication year - 2013
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4318
Subject(s) - diethanolamine , amine gas treating , fourier transform infrared spectroscopy , gel permeation chromatography , hydrolysis , aqueous solution , chemistry , polymer chemistry , polymer , infrared spectroscopy , nuclear chemistry , organic chemistry , chemical engineering , engineering
The synthesis of hyperbranched polyphosphoramidate (HPPAE) has been successfully achieved via a facial A 2 + CB 2 approach. First, an AB 2 type intermediate is generated by the reaction between the phosphorus chloride group of ethyldichlorophosphate and the secondary amine group of diethanolamine. Second, the above intermediate can further self‐condense to produce the hyperbranched polymer. The molecular weight and the structural characterization of HPPAE were checked by gel permeation chromatography and Fourier transform infrared and NMR ( 13 C and 31 P) spectroscopy. The degradation study of HPPAE indicated that phosphate and phosphoramide bonds between the branch points are responsible for its complete hydrolysis in an aqueous phosphate buffer (pH 7.4) after 6 days. In addition, HPPAE presents a strong fluorescence peak at 450 nm, exhibiting the potential to track drug transport and distribution in real time. © 2012 Society of Chemical Industry