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Synthesis and characterization of new biodegradable comb‐dendritic triblock copolymers
Author(s) -
Ju Mingjie,
Shen Li,
Gong Feirong,
Gao Yun,
Zhang Weian
Publication year - 2012
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.4231
Subject(s) - materials science , differential scanning calorimetry , copolymer , crystallinity , polymer chemistry , gel permeation chromatography , crystallization , fourier transform infrared spectroscopy , dynamic light scattering , chemical engineering , ethylene glycol , glass transition , polymer , composite material , nanotechnology , physics , nanoparticle , engineering , thermodynamics
A series of well‐defined dumbbell‐shaped triblock copolymers consisting of linear poly(ethylene glycol) (PEG) and comb‐like poly(ε‐caprolactone) (PCL) with varied PCL arm lengths have been synthesized via the sequential preparation of different generation terminal dendronized PEG and ring‐opening polymerization of ε‐caprolactone. The copolymers were characterized using Fourier transform infrared, 1 H NMR and 13 C NMR spectroscopy and gel permeation chromatography. Differential scanning calorimetry was performed to measure the glass transition temperature, melting point and degree of crystallinity and the PEG segment and PCL segment crystallization temperatures. The crystallization of the copolymers was also studied using X‐ray diffraction. The dumbbell‐shaped copolymers were further used to construct microspheres using a double emulsion method. Scanning electron microscopy and dynamic light scattering results showed the size of the microspheres was about 2 to 4 µm and the size distribution was quite narrow. Copyright © 2012 Society of Chemical Industry