Premium
Strong resistance of poly (ethylene glycol) based L ‐tyrosine polyurethanes to protein adsorption and cell adhesion
Author(s) -
Yang JuiChen,
Zhao Chao,
Hsieh IFan,
Subramanian Senthilram,
Liu Lingyun,
Cheng Gang,
Li Lingyan,
Cheng Stephen Z. D.,
Zheng Jie
Publication year - 2012
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.3220
Subject(s) - protein adsorption , polyurethane , ethylene glycol , adhesion , adsorption , peg ratio , biofouling , cell adhesion , materials science , chemical engineering , polymer chemistry , chemistry , organic chemistry , biochemistry , composite material , finance , membrane , engineering , economics
Biofouling that involves protein adsorption, cell and bacteria adhesion, and biofilm formation between a surface and biological entities is a great challenge for biomedical and industry applications. In this work, L ‐tyrosine‐derived polyurethanes ( L ‐polyurethane) with different molecular weights of poly(ethylene glycol) (PEG) were synthesized, characterized and coated on gold surfaces using spin‐coating. The non‐fouling activity of different L ‐polyurethane films was evaluated by protein adsorption and cell adhesion. Surface plasmon resonance and cell assay results demonstrate that the PEG content in these L ‐polyurethanes contributes excellent resistance to protein adsorption and cell attachments. This work provides alternative and effective biomaterials for potential applications in blood‐contacting devices. Copyright © 2011 Society of Chemical Industry
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom