Premium
Strong resistance of poly (ethylene glycol) based L ‐tyrosine polyurethanes to protein adsorption and cell adhesion
Author(s) -
Yang JuiChen,
Zhao Chao,
Hsieh IFan,
Subramanian Senthilram,
Liu Lingyun,
Cheng Gang,
Li Lingyan,
Cheng Stephen Z. D.,
Zheng Jie
Publication year - 2012
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.3220
Subject(s) - protein adsorption , polyurethane , ethylene glycol , adhesion , adsorption , peg ratio , biofouling , cell adhesion , materials science , chemical engineering , polymer chemistry , chemistry , organic chemistry , biochemistry , composite material , finance , membrane , engineering , economics
Abstract Biofouling that involves protein adsorption, cell and bacteria adhesion, and biofilm formation between a surface and biological entities is a great challenge for biomedical and industry applications. In this work, L ‐tyrosine‐derived polyurethanes ( L ‐polyurethane) with different molecular weights of poly(ethylene glycol) (PEG) were synthesized, characterized and coated on gold surfaces using spin‐coating. The non‐fouling activity of different L ‐polyurethane films was evaluated by protein adsorption and cell adhesion. Surface plasmon resonance and cell assay results demonstrate that the PEG content in these L ‐polyurethanes contributes excellent resistance to protein adsorption and cell attachments. This work provides alternative and effective biomaterials for potential applications in blood‐contacting devices. Copyright © 2011 Society of Chemical Industry