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Preparation of silk fibroin–poly(ethylene glycol) conjugate films through click chemistry
Author(s) -
Sampaio Sandra,
Miranda Teresa M. R.,
Santos Jorge G.,
Soares Graça M. B.
Publication year - 2011
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.3143
Subject(s) - fibroin , ethylene glycol , click chemistry , polymer chemistry , differential scanning calorimetry , peg ratio , acetylene , materials science , alkyne , chemistry , fourier transform infrared spectroscopy , chemical engineering , silk , organic chemistry , catalysis , composite material , physics , finance , economics , thermodynamics , engineering
Azide silk fibroin (azido SF) and alkyne terminal poly(ethylene glycol) (PEG) 2000 (acetylene‐terminal PEG 2000) were synthesized. Azido SF was reacted with acetylene‐terminal PEG 2000 to produce films via a copper‐mediated 1,3‐cycloaddition (‘click’ chemistry) generating a triazole linkage as the networking forming reaction. Through click chemistry, novel silk‐based films with various weight ratios were prepared and investigated. Fourier transform infrared, X‐ray diffraction and differential scanning calorimetry analyses showed that the ordered association of the PEG molecules is strongly constrained by the presence of the SF molecules and crosslinking and that the presence of acetylene‐terminal PEG 2000 in the films induced crystallization to a β‐sheet of SF chains. Water content and contact angle measurements indicated that the hydrophilicity of the films increased compared with SF. SF–PEG films exhibited smooth and rough structures, depending on degree of crosslinking and on the weight ratio of SF and PEG, as shown by scanning electron microscopy. Copyright © 2011 Society of Chemical Industry