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Multifunctional hybrid magnetite nanoparticles with pH‐responsivity, superparamagnetism and fluorescence
Author(s) -
Zhou Lilin,
Cai Zhinan,
Yuan Jinying,
Kang Yan,
Yuan Weizhong,
Shen Dezhong
Publication year - 2011
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.3081
Subject(s) - superparamagnetism , methacrylate , nanoparticle , materials science , fluorescence , drug delivery , chemical engineering , nanotechnology , fluorescence spectroscopy , fluorescence microscope , magnetic nanoparticles , copolymer , polymer , magnetization , optics , physics , engineering , quantum mechanics , magnetic field , composite material
Multifunctional hybrid nanoparticles, Fe 3 O 4 @poly[(2‐dimethylamino)ethyl methacrylate]‐ block ‐poly(2‐hydroxyethyl methacrylate)‐ graft ‐carbazole, with pH‐responsivity, superparamagnetism and fluorescence for targeted drug delivery and release have been synthesized. The nanoparticles have a core‐shell structure as determined from transmission electron microscopy, pH‐responsivity as determined from hydrodynamic radius analysis, superparamagnetism as determined from vibrating sample magnetometry and fluorescence as determined from fluorescence spectroscopy and fluorescence microscopy. The release behavior of model drug progesterone indicates that the release rate can be effectively controlled by altering the pH of the environment. The multifunctional nanoparticles could be applied extensively in targeted drug delivery and release, and with fluorescence they can serve as efficient tracers to record magnetic targeting routes. Copyright © 2011 Society of Chemical Industry