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Porous silicone hydrogel interpenetrating polymer networks prepared using a template method for biomedical use
Author(s) -
Tang Qi,
Yu JunRong,
Chen Lei,
Zhu Jing,
Hu ZuMing
Publication year - 2011
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.3053
Subject(s) - polydimethylsiloxane , swelling , silicone , materials science , self healing hydrogels , copolymer , methacrylate , polymer , interpenetrating polymer network , porosity , chemical engineering , polymer chemistry , drug delivery , composite material , nanotechnology , engineering
Porous interpenetrating polymer networks (IPNs) of polydimethylsiloxane with hydrophilic components synthesized by radical homopolymerization and copolymerization of 2‐hydroxyethyl methacrylate (HEMA) and N , N ‐dimethylacrylamide (DMAA) were obtained using a template method. Surface modification of CaCO 3 microsphere templates improved their dispersibility, leading to the realization of IPN films with an interconnected porous structure. Results showed that these porous IPN films exhibited higher swelling abilities, and thus better drug loading capabilities than the corresponding non‐porous films. In addition, IPNs comprised of DMAA exhibited higher swelling abilities and faster drug release rates than those of only HEMA. These silicone hydrogels were also tested for their cytotoxicity against L929 cells, confirming their non‐toxicity to cells and their potential use as materials for biomedical applications. Copyright © 2011 Society of Chemical Industry