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Optimization of N , N , N ‐trimethylchitosan synthesis by factorial design
Author(s) -
de Britto Douglas,
Frederico Fernando R,
Garrido Assis Odilio B
Publication year - 2011
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.3038
Subject(s) - depolymerization , factorial experiment , solubility , yield (engineering) , factorial , degree (music) , permeation , gel permeation chromatography , chemistry , chemical engineering , polymer chemistry , materials science , mathematics , organic chemistry , polymer , composite material , biochemistry , membrane , physics , mathematical analysis , statistics , acoustics , engineering
Factorial design analysis was applied to optimize the synthesis, via a new route, of N , N , N ‐trimethylchitosan, based on dimethylsulfate as a methylating agent. The responses analyzed were weight yield, solubility and average degree of quaternization. Temperature was verified as the most important variable, as it caused the most variation in the response. X ( T ) = − 54.52, − 9.50 and − 7.25, respectively, for weight yield, solubility and degree of quaternization. A sharp decrease in the viscosimetric and gel permeation chromatography parameters proved that severe depolymerization took place at high reaction temperatures. Contact angle measurements showed a decrease in the hydrophilic character of over‐methylated samples. Copyright © 2011 Society of Chemical Industry