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New chemoenzymatic‐facilitated synthesis of diblock copolymers and biomedically appropriate vesicles
Author(s) -
Li Meng,
Wang Wei,
Pan Si,
Zhang Bao,
Wang Jingyuan
Publication year - 2008
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.2484
Subject(s) - atom transfer radical polymerization , copolymer , polymerization , polymer , polymer chemistry , methacrylate , glycidyl methacrylate , materials science , amphiphile , gel permeation chromatography , radical polymerization , chemistry , chemical engineering , organic chemistry , engineering
BACKGROUND: Biocatalytic approaches in polymer science are expected to further increase the diversity of polymeric materials. And the full exploitation of biocatalysis in polymer science will require the development of compatible chemoenzyme‐catalyzed methods. RESULTS: The well‐defined diblock copolymer poly(2,2,2‐trichloroethanol 10‐hydroxydecanate)‐ block ‐poly(glycidyl methacrylate) (P(TCE‐10‐HD)‐ b ‐PGMA) was obtained by combining enzymatic condensation polymerization and atom transfer radical polymerization (ATRP). P(TCE‐10‐HD) was prepared by enzymatic condensation polymerization of 10‐hydroxydecanoic acid and 2,2,2‐trichloroethanol. This CCl 3 ‐terminated polyester permitted subsequent ATRP of glycidyl methacrylate. Kinetic studies indicated a ‘living’ controlled radical polymerization. The self‐assembly behavior of the amphiphilic diblock copolymer, in tetrahydrofuran/water, gave rise to aggregates with diameters ranging from 160 to 240 nm. The morphology of the assembly particles was studied using atomic force microscopy, transmission electron microscopy and scanning electron microscopy. CONCLUSION: To obtain the ATRP macromolecular initiator, this one‐step method is more convenient than other two‐step methods. The results of NMR, Fourier transform infrared and gel permeation chromatography analyses testified that this method is feasible. The formulated vesicles have great potential as biomedical materials. Copyright © 2008 Society of Chemical Industry