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Preparation, characterization and preliminary calcium release study of floating sodium alginate/dextran‐based hydrogel beads: part I
Author(s) -
Bajpai Sunil Kumar,
Tankhiwale Rasika
Publication year - 2008
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.2311
Subject(s) - buoyancy , dextran , calcium , diffusion , calcium alginate , chemical engineering , bead , sodium alginate , materials science , kinetics , chemistry , sodium , compressibility , chromatography , polymer chemistry , composite material , organic chemistry , thermodynamics , physics , quantum mechanics , engineering
Ionically crosslinked calcium alginate/dextran‐based floating beads were prepared using NaHCO 3 as porogen. Various micrometric properties such as tapped density, apparent density, compressibility index, etc., were determined for beads with different compositions. The beads were also evaluated for their mechanical strength. The percent buoyancy of the beads was measured as a function of time in simulated gastric fluid (pH = 1.2 at 37 °C). The beads prepared with higher concentrations of NaHCO 3 porogen and CaCl 2 crosslinker possessed 100% buoyancy and remained buoyant for nearly 20 h, or even more. Finally, the release of calcium from the beads was observed to follow diffusion‐controlled Higuchi kinetics. Copyright © 2007 Society of Chemical Industry