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Factors affecting the degradation and drug‐release mechanism of poly(lactic acid) and poly[(lactic acid)‐ co ‐(glycolic acid)]
Author(s) -
Alexis Frank
Publication year - 2005
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.1697
Subject(s) - crystallinity , degradation (telecommunications) , lactic acid , polymer , glycolic acid , chemical engineering , polymer degradation , materials science , copolymer , drug delivery , polymer chemistry , drug , chemistry , organic chemistry , composite material , pharmacology , computer science , genetics , medicine , telecommunications , biology , bacteria , engineering
This paper reviews the most important factors affecting the degradation and drug‐release rate of bio‐erodible polymers for better control in biomedical applications. There are several factors that influence the overall rate of degradation, in addition to pH and copolymer composition. In general, polymer degradation is accelerated by greater hydrophilicity in the backbone or end groups, lesser crystallinity, lower average molecular weight, and smaller size of the finished device. At the moment, literature reflects contradictions about the role played by chemically reactive additives, crystallinity and degradation path. Factors affecting degradation and drug‐release rate are discussed in their decreasing order of importance, including intrinsic properties of polymers and processing parameters. Copyright © 2004 Society of Chemical Industry