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Blood protein adsorption onto a polymeric biomaterial of polyethylene glycol and poly[(2‐hydroxyethyl methacrylate)‐ co ‐acrylonitrile] and evaluation of in vitro blood compatibility
Author(s) -
Bajpai AK
Publication year - 2005
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.1673
Subject(s) - adsorption , acrylonitrile , methacrylate , 2 hydroxyethyl methacrylate , polyethylene glycol , protein adsorption , ionic strength , polymer chemistry , materials science , (hydroxyethyl)methacrylate , chemical engineering , polymer , sorption , peg ratio , bovine serum albumin , chemistry , nuclear chemistry , chromatography , polymerization , organic chemistry , composite material , aqueous solution , copolymer , finance , economics , engineering
A semi‐interpenetrating polymer network (semi‐IPN) of polyethylene glycol (PEG) and crosslinked poly[(2‐hydroxyethyl methacrylate)‐ co ‐acrylonitrile] was prepared and adsorption of bovine serum albumin (BSA) on the IPN surfaces was investigated. The dynamic nature of the adsorption process was studied, and the effects of various experimental factors such as pH and ionic strength on the adsorption isotherms of BSA were investigated. Various kinetic parameters, such as the adsorption coefficient, rate constant for adsorption and penetration rate constants, were calculated. For assessment of in vitro blood compatibility of the IPN surfaces, water sorption, blood clot formation tests and percent hemolysis measurements were performed. Copyright © 2004 Society of Chemical Industry