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Biodegradable hollow microfibres to produce bioactive scaffolds
Author(s) -
Lazzeri Luigi,
Cascone Maria Grazia,
Quiriconi Simone,
Morabito Letterio,
Giusti Paolo
Publication year - 2005
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.1648
Subject(s) - materials science , differential scanning calorimetry , scanning electron microscope , emulsion , spinning , substrate (aquarium) , ultimate tensile strength , polylactic acid , composite material , scaffold , chemical engineering , biomedical engineering , polymer , medicine , oceanography , physics , engineering , thermodynamics , geology
Biodegradable hollow microfibres containing particles loaded with specific active agents can be potentially employed to produce a special kind of substrate for tissue engineering, able to function as a scaffold and at the same time to act as a drug‐releasing system. Biodegradable hollow microfibres based on poly(lactic acid) were produced by a dry–wet spinning procedure. Drug‐loaded microparticles were prepared by a simple oil‐in‐water emulsion and entrapped inside the fibres. The morphology of both fibres and particles was investigated by scanning electron microscopy. The mechanical and thermal properties of the fibres were investigated by tensile tests and differential scanning calorimetry. In vitro tests were performed to evaluate the release of the drug from the fibres loaded with the particles Copyright © 2004 Society of Chemical Industry