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Characterisation of grafted supports used for solid‐phase synthesis
Author(s) -
Blakey Idriss,
Day Gary,
Girjes Ebtihal,
Hunter David S,
Rasoul Firas
Publication year - 2003
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.1300
Subject(s) - polypropylene , polystyrene , materials science , styrene , polymer chemistry , raman spectroscopy , polymerization , chemical engineering , swelling , composite material , polymer , copolymer , optics , physics , engineering
A series of ‘pellicular’ type supports were fabricated by direct gamma‐radiation‐mediated graft polymerisation of styrene onto polypropylene, followed by aminomethylation. Raman spectroscopy was used for measuring the level of penetration of polystyrene graft into polypropylene, and other structural features such as density of graft and depth of functionalisation. The kinetics of the coupling of fluorenylmethylcarbamate (Fmoc)‐labelled amino acids, to the aminomethylated polystyrene grafts have been measured by UV absorption followed cleavage of the Fmoc chromophore. The Raman spectroscopy results showed that for this series of experiments the calculated rate coefficient for coupling of Fmoc‐labelled amino acids was primarily dependent on graft thickness, but was also influenced by the proportion of polystyrene graft to polypropylene. In general, it was also shown that with increasing loading capacity of support the calculated rate coefficient for amino‐acid coupling decreased correspondingly. In addition, a support that had both a high rate coefficient and a high loading capacity was prepared from polypropylene base material with a co‐continuous porous structure (high surface area). Copyright © 2003 Society of Chemical Industry