Formulation of solid products: two‐component tablets with a disintegrating agent | Zendy

Hutin S | Zendy; Accart P | Zendy; Oulahna D | Zendy; Dodds JA | Zendy

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Formulation of solid products: two‐component tablets with a disintegrating agent

Author(s) -

Hutin S,

Accart P,

Oulahna D,

Dodds JA

Publication year - 2003

Publication title -

polymer international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.592

H-Index - 105

eISSN - 1097-0126

pISSN - 0959-8103

DOI - 10.1002/pi.1194

Subject(s) - component (thermodynamics) , biochemical engineering , engineering , physics , thermodynamics

The formulation of binary tablets containing an insoluble powder and a disintegrating agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine–starch, cocoa–ultrafine sugar and cocoa–icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions. Copyright © 2003 Society of Chemical Industry

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