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Biologically active polymer: controlled‐release formulations based on Hymexazol
Author(s) -
Tai Limin,
Liu Dongxue,
Shen Yongjia,
Si Naiguo
Publication year - 2002
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.1035
Subject(s) - copolymer , acrylamide , hydrolysis , methacrylate , polymer , polymer chemistry , high performance liquid chromatography , chemistry , controlled release , chemical structure , nuclear chemistry , materials science , organic chemistry , nanotechnology
3‐(2‐Hydroxyethoxy)‐5‐methylisoxazole ( 2 ) was prepared by the reaction of 3‐hydroxy‐5‐methylisoxazole ( 1 ) with 2‐ethylene chlorohydrin. It reacted with methacryloyl chloride to afford 2‐[3‐(5‐methylisoxazolyl)oxy]ethyl methacrylate ( 4 ). The compounds 2 and 4 were confirmed structurally by IR, MASS and 1 H NMR spectroscopy and MS. The fungicidal effects of 2 and 4 were investigated. Compound 4 was subjected to radical copolymerization with acrylamide and formed a copolymer 5 . It would release the active agent 2 in a reasonable amount by a hydrolysis process. The release rates of the compound 2 were determined by high performance liquid chromatography (HPLC) under different pH conditions. The results indicate that the copolymer 5 is potentially useful for the development of the chemically controlled‐released formulations of Hymexazol. © 2002 Society of Chemical Industry