Biologically active polymer: controlled‐release formulations based on Hymexazol | Zendy

Tai Limin | Zendy; Liu Dongxue | Zendy; Shen Yongjia | Zendy; Si Naiguo | Zendy

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Biologically active polymer: controlled‐release formulations based on Hymexazol

Author(s) -

Tai Limin,

Liu Dongxue,

Shen Yongjia,

Si Naiguo

Publication year - 2002

Publication title -

polymer international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.592

H-Index - 105

eISSN - 1097-0126

pISSN - 0959-8103

DOI - 10.1002/pi.1035

Subject(s) - copolymer , acrylamide , hydrolysis , methacrylate , polymer , polymer chemistry , high performance liquid chromatography , chemistry , controlled release , chemical structure , nuclear chemistry , materials science , organic chemistry , nanotechnology

3‐(2‐Hydroxyethoxy)‐5‐methylisoxazole ( 2 ) was prepared by the reaction of 3‐hydroxy‐5‐methylisoxazole ( 1 ) with 2‐ethylene chlorohydrin. It reacted with methacryloyl chloride to afford 2‐[3‐(5‐methylisoxazolyl)oxy]ethyl methacrylate ( 4 ). The compounds 2 and 4 were confirmed structurally by IR, MASS and 1 H NMR spectroscopy and MS. The fungicidal effects of 2 and 4 were investigated. Compound 4 was subjected to radical copolymerization with acrylamide and formed a copolymer 5 . It would release the active agent 2 in a reasonable amount by a hydrolysis process. The release rates of the compound 2 were determined by high performance liquid chromatography (HPLC) under different pH conditions. The results indicate that the copolymer 5 is potentially useful for the development of the chemically controlled‐released formulations of Hymexazol. © 2002 Society of Chemical Industry

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