Preparation and blood compatibility of phosphorylcholine‐bonded  O ‐butyrylchitosan | Zendy

Zhu Aiping | Zendy; Shan Bing | Zendy; Yuan Youling | Zendy; Shen Jian | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Preparation and blood compatibility of phosphorylcholine‐bonded O ‐butyrylchitosan

Author(s) -

Zhu Aiping,

Shan Bing,

Yuan Youling,

Shen Jian

Publication year - 2003

Publication title -

polymer international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.592

H-Index - 105

eISSN - 1097-0126

pISSN - 0959-8103

DOI - 10.1002/pi.1026

Subject(s) - phosphorylcholine , chemistry , clotting time , platelet , biochemistry , biology , immunology

2‐Methacryloyloxyethyl phosphorylcholine (MPCE) was synthesized using phosphorus trichloride, ethylene glycol, 2‐hydroxyethyl methacrylate and triethylamine, and then used in the preparation of O ‐butyrylchitosan‐bonded MPCE (MPCE–BCS) by Michael addition of MPCE to amino groups of O ‐butyrylchitosan. The structures of MPCE and MPCE–BCS were characterized by FTIR and 1 H NMR. The blood‐compatibility of MPCE–BCS was evaluated by means of blood clotting and platelet adhesion assays. The blood‐clotting assay indicated that O ‐butyrylchitosan was haemocompatible. Both the blood‐clotting assay and platelet adhesion assay confirmed that MPCE–BCS had excellent antithrombogenicity. © 2003 Society of Chemical Industry

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research