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Preparation and blood compatibility of phosphorylcholine‐bonded O ‐butyrylchitosan
Author(s) -
Zhu Aiping,
Shan Bing,
Yuan Youling,
Shen Jian
Publication year - 2003
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/pi.1026
Subject(s) - phosphorylcholine , chemistry , clotting time , platelet , biochemistry , biology , immunology
2‐Methacryloyloxyethyl phosphorylcholine (MPCE) was synthesized using phosphorus trichloride, ethylene glycol, 2‐hydroxyethyl methacrylate and triethylamine, and then used in the preparation of O ‐butyrylchitosan‐bonded MPCE (MPCE–BCS) by Michael addition of MPCE to amino groups of O ‐butyrylchitosan. The structures of MPCE and MPCE–BCS were characterized by FTIR and 1 H NMR. The blood‐compatibility of MPCE–BCS was evaluated by means of blood clotting and platelet adhesion assays. The blood‐clotting assay indicated that O ‐butyrylchitosan was haemocompatible. Both the blood‐clotting assay and platelet adhesion assay confirmed that MPCE–BCS had excellent antithrombogenicity. © 2003 Society of Chemical Industry