
The cerebrovascular response to graded Valsalva maneuvers while standing
Author(s) -
Perry Blake G.,
Mündel Toby,
Cochrane Darryl J.,
Cotter James D.,
Lucas Samuel J. E.
Publication year - 2014
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.1002/phy2.233
Subject(s) - medicine , blood pressure , middle cerebral artery , mean arterial pressure , cardiology , perfusion , anesthesia , heart rate , ischemia
The Valsalva maneuver ( VM ) produces large and abrupt increases in mean arterial pressure ( MAP ) at the onset of strain (Phase I), however, hypotension, sufficient to induce syncope, occurs upon VM release (phase III). We examined the effect of VM intensity and duration on middle cerebral artery blood velocity ( MCA v) responses. Healthy men ( n = 10; mean ± SD : 26 ± 4 years) completed 30%, 60%, and 90% of their maximal VM mouth pressure, for 5 and 10 sec (order randomized) while standing. Beat‐to‐beat MCA v and MAP during phase I (peak), at nadir (phase III), and recovery are reported as the change from standing baseline. During phase I, MCA v rose 15 ± 6 cm·s −1 ( P < 0.001), which was not reliably different between intensities ( P = 0.11), despite graded increases in MAP ( P < 0.001; e.g., +12 ± 9 mmHg vs. +35 ± 14 for 5 sec 30% and 90% VM , respectively). During Phase III, the MCA v response was duration‐ ( P = 0.045) and intensity dependent ( P < 0.001), with the largest decrease observed following the 90% VM (e.g., −19 ± 13 and −15 ± 11 cm·s −1 for 5 and 10 sec VM , respectively) with a concomitant decrease in MAP ( P < 0.001, −23 ± 11 and −23 ± 9 mmHg). This asymmetric response may be attributable to the differential modulators of MCA v throughout the VM . The mechanical effects of the elevated intrathoracic pressure during phase I may restrain increases in cerebral perfusion via related increases in intracranial pressure; however, during phase III the decrease in MCA v arises from an abrupt hypotension, the extent of which is dependent upon both the duration and intensity of the VM .