Posttranslational regulation of tissue inhibitor of metalloproteinase‐1 by calcium‐dependent vesicular exocytosis | Zendy

Dranoff Jonathan A. | Zendy; Bhatia Neal | Zendy; Fausther Michel | Zendy; Lavoie Elise G. | Zendy; Granell Susana | Zendy; Baldini Giulia | Zendy; Hickman DaShawn A. | Zendy; Sheung Nina | Zendy

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Posttranslational regulation of tissue inhibitor of metalloproteinase‐1 by calcium‐dependent vesicular exocytosis

Author(s) -

Dranoff Jonathan A.,

Bhatia Neal,

Fausther Michel,

Lavoie Elise G.,

Granell Susana,

Baldini Giulia,

Hickman DaShawn A.,

Sheung Nina

Publication year - 2013

Publication title -

physiological reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 39

ISSN - 2051-817X

DOI - 10.1002/phy2.125

Subject(s) - exocytosis , hepatic stellate cell , myofibroblast , metalloproteinase , tissue inhibitor of metalloproteinase , microbiology and biotechnology , fibrosis , matrix metalloproteinase , chemistry , cancer research , biology , medicine , pathology , extracellular matrix , biochemistry , secretion

Liver myofibroblasts derived from hepatic stellate cells ( HSC ) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase‐1 ( TIMP ‐1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP ‐1 by myofibroblastic HSC are unknown. Here, we demonstrate that TIMP ‐1 release by HSC is regulated in a posttranslational fashion via calcium‐sensitive vesicular exocytosis. To our knowledge, this is the first article to directly examine vesicular trafficking in myofibroblastic HSC , potentially providing a new target to treat and or prevent liver fibrosis.

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