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Myocardial infarction associated with erenumab: A case report
Author(s) -
Perino Justine,
Corand Virginie,
Laurent Elise,
Théophile Hélène,
MiremontSalamé Ghada,
Pariente Antoine,
Colas JeanLaurent,
Couffinhal Thierry,
Salvo Francesco
Publication year - 2022
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.2706
Subject(s) - medicine , myocardial infarction , calcitonin gene related peptide , migraine , chest pain , troponin , cardiology , infarction , calcitonin , abnormality , receptor , neuropeptide , psychiatry
Background Monoclonal antibodies acting on the calcitonin gene‐related peptide or its receptor (CGRP‐mabs) are novel drugs for resistant migraine prophylaxis. As CGRP‐mabs cause inhibition of vasodilatation, their use is reserved to patients with no recent history of cardiovascular diseases. We report a case of myocardial infarction associated with erenumab. Case A 57‐year‐old woman with a familial history of coronaropathy was first treated with erenumab 70 mg for 6 months and then increased to 140 mg. Almost 5 months after, the patient presented chest pain, increased troponin, and abnormal electrocardiogram. A myocardial infarction without coronarography abnormality was diagnosed through MRI. Conclusion Further evidence is needed to assess the risk of myocardial infarction in patients treated with a CGRP‐mab. In patients over 40 years of age, the risk of coronary or cardiovascular events should be assessed using risk tables or algorithms to take into account cardiovascular risk factors. This may be complemented by appropriate examinations to measure the burden of coronary atherosclerosis, if necessary.