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Ventilatory and Pharmacotherapeutic Strategies for Management of Adult Patients on Extracorporeal Life Support
Author(s) -
Dzierba Amy L.,
Abrams Darryl,
Muir Justin,
Brodie Daniel
Publication year - 2019
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.2230
Subject(s) - medicine , extracorporeal , life support , intensive care medicine , sedation , dosing , respiratory failure , anesthesia , surgery
Extracorporeal life support ( ECLS ) can provide mechanical support for patients with severe life‐threatening cardiac or respiratory failure. ECLS is a complex therapy that has increased in use over several decades owing to advances in technology. In concert with this growth, there is an increased need to understand the complexity of this technology to augment the effectiveness of ECLS and minimize complications such as ventilator‐induced lung injury, bleeding, thrombosis, infections, and inadequate drug dosing. The purpose of this review was to discuss management strategies in adult patients receiving ECLS and provide recommendations on ventilator management, provision of adequate analgesia and sedation, treatment and prevention of infections, and anticoagulation.