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Vasoactive Agent Use in Septic Shock: Beyond First‐Line Recommendations
Author(s) -
Sacha Gretchen L.,
Bauer Seth R.,
Lat Ishaq
Publication year - 2019
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.2220
Subject(s) - septic shock , medicine , intensive care medicine , norepinephrine , vasoactive , shock (circulatory) , perfusion , sepsis , cardiology , dopamine
Septic shock is a life‐threatening disorder associated with high mortality rates requiring rapid identification and intervention. Vasoactive agents are often required to maintain goal hemodynamics and preserve tissue perfusion. However, guidance regarding the proper administration of adjunct agents for the management of septic shock is limited in patients who are refractory to norepinephrine. This review summarizes vasopressor agents and describes the nuanced application of these agents in patients with septic shock, specifically focusing on clinical scenarios with limited guidance including patients who are nonresponsive to first‐line agents and individuals with mixed shock states, tachyarrhythmias, obesity, valvular abnormalities, or other comorbid conditions.