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2018 ACCP Virtual Poster Symposium
Author(s) -
Sunita Dergalust,
Keith Yuge,
Hyo-Jin Chae,
Leah Loewenstein,
Frank,
Bertone,
Mary Porter,
Jennifer Lim,
Meghan Soso
Publication year - 2018
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.2144
Subject(s) - citation , computer science , library science , world wide web
1. Evaluation of adverse drug events leading to hospitalizations at VA greater Los Angeles healthcare system. Joseph Wang, Pharm.D., Sunita Dergalust, Pharm.D., BCPS, Keith Yuge, BS, Hyo-Jin Chae, Pharm.D., Leah Loewenstein, Pharm.D., Frank Bertone, Pharm.D., BCPS, Mary Porter, Pharm.D., BCPS; Pharmacy, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA INTRODUCTION: Adverse drug events (ADEs) represent 5–7% of all hospitalizations, with over half deemed preventable. In addition, they also account for 5–9% of total hospitalization costs per annum. ADEs are more prevalent in the elderly population due to age-related changes in pharmacokinetics and pharmacodynamics, polypharmacy, and multiple comorbidities. This increase in susceptibility to ADEs in the elderly leads to an increase in the amount of hospitalizations due to ADEs. RESEARCH QUESTION OR HYPOTHESIS: Is there a trend in ADEs leading to hospitalizations at VA Greater Los Angeles Healthcare System (VAGLAHS)? STUDY DESIGN: Retrospective chart review. METHODS: Patients who were hospitalized at VAGLAHS due to an ADE between January 1, 2003 and March 31, 2017 were identified. Patient demographics, number of comorbidities and regularly scheduled medications, drug class causing ADE, ADE description, baseline renal and hepatic function, length of hospital stay, and interventions were collected. RESULTS: Approximately 4,000 ADEs were reported during the data collection period with 10% of the ADEs leading to hospitalizations. Approximately 30% of the patients were hospitalized for angioedema related to angiotensin converting enzyme inhibitors (ACE-I),with 76%of the cases occurring inAfrican-Americans.Cardiovascular drugs and antibiotics were identified as causative agents in 47.4% and 24.3% of the ADEs that have led to hospitalizations, respectively. The average age of patients admitted was 65 years old and 54.6%of the patients presentedwithmore than eight comorbidities while 49.3%of the patientswere onmore than nine chronicmedications.Theaverage lengthofhospital staywas7 days. CONCLUSION: ACE-I induced angioedema was the most prevalent reported ADE leading to hospitalizations at VAGLAHS. This ADE occurs in 0.2% of the general population and 3 to 4 times higher in African-Americans. Further investigation into this reaction is warranted in the veteran population for future prevention of hospitalizations related to this ADE.