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New Thoughts on the “Forgotten” Aspect of Antimicrobial Stewardship: Adverse Event Reporting
Author(s) -
Hoffmann Charles,
Khadem Tina,
Schweighardt Anne,
Brown Jack
Publication year - 2015
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.1524
Subject(s) - antimicrobial stewardship , medicine , adverse effect , intensive care medicine , antimicrobial , adverse event reporting system , stewardship (theology) , pharmacovigilance , patient safety , health care , pharmacology , antibiotics , antibiotic resistance , chemistry , organic chemistry , politics , political science , law , microbiology and biotechnology , biology , economics , economic growth
Antimicrobial stewardship is an activity that optimizes patient care through selection of the most appropriate antimicrobial therapy. Antimicrobial stewardship programs strive to enhance patient care and reduce preventable consequences of antimicrobial use. They are also vital in monitoring for the development of adverse events occurring as a result of antimicrobial therapy, although literature reviews of this activity are scarce. Although randomized controlled trials are considered the gold standard to study the efficacy of a medication, these trials are not designed to test safety end points and often are only able to identify the most commonly occurring and acute adverse events. In addition, prior to a drug going to market, it is difficult to detect rare adverse events because the associated costs are economically untenable given the limited pipeline of novel agents. These limitations in some ways may be resolved with the use of postmarketing surveillance and spontaneous reporting systems such as the United States Food and Drug Administration Adverse Event Reporting System. The focus of this commentary is to highlight the importance of adverse event reporting by antimicrobial stewardship programs to spontaneous reporting systems as a means to improve patient care.