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Acute Coronary Syndrome Antiplatelet Alternatives in Clopidogrel Allergy
Author(s) -
Manchette Anastasia M.,
Drucker Adrienne G.,
Januzzi James L.
Publication year - 2014
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.1446
Subject(s) - ticagrelor , clopidogrel , medicine , acute coronary syndrome , allergy , aspirin , intensive care medicine , myocardial infarction , immunology
No published information exists to support the safe use of ticagrelor in patients with a clopidogrel allergy. This study involved an institutional review board–approved retrospective review of patients with a documented clopidogrel allergy who subsequently received ticagrelor between July 2011 and February 2014. We report the cases of two patients with a history of hypersensitivity to clopidogrel in whom ticagrelor was used successfully without documented incident. In addition, principles suggesting a lack of cross‐sensitivity between ticagrelor and clopidogrel are reviewed. These cases combined with theoretical evidence support the use of ticagrelor in patients with hypersensitivity to clopidogrel.