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Ceftaroline‐Induced Eosinophilic Pneumonia
Author(s) -
Desai Kunal R.,
Burdette Steven D.,
Polenakovik Hari M.,
Hagaman Jared,
Pleiman Craig M.
Publication year - 2013
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/phar.1286
Subject(s) - eosinophilic pneumonia , medicine , bronchoalveolar lavage , eosinophilia , pulmonary eosinophilia , pneumonia , discontinuation , eosinophilic , hypersensitivity pneumonitis , pathology , lung
We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin‐resistant S taphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed diffuse bilateral infiltrates. Laboratory abnormalities included peripheral eosinophilia and eosinophilic predominant bronchoalveolar lavage fluid. The combination of ceftaroline discontinuation plus initiation of steroid treatment resulted in complete resolution of signs, symptoms, and radiologic abnormalities. We speculate about possible mechanisms underlying this adverse event and diagnostic criteria for drug‐induced eosinophilic pneumonia.