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Publication year - 2021
Publication title -
peptide science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24241
Subject(s) - cover (algebra) , combinatorial chemistry , computer science , citation , disulfide bond , chemistry , information retrieval , stereochemistry , world wide web , engineering , mechanical engineering , biochemistry
Ziconotide is a synthetic version of ω‐MVIIA, a conopeptide. It is a non‐opioid analgesic and has been approved for use in many countries. Jae Eun Kang and co‐workers report a facile coupling process for the high‐purity synthesis of a linear precursor of Ziconotide using a judicious choice of coupling agents. They also report simple folding conditions that facilitate the formation of Ziconotide possessing the correct disulfide connectivity and three‐dimensional conformation. The process avoids multiple isolation and purification steps, as well as eliminating the need for many additives currently used in the synthesis of Ziconotide and other cysteine‐rich peptides. (doi: 10.1002/pep2.24223 )