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Effect of side chain phenyl group on the self‐assembled morphology of dipeptide hydrazides
Author(s) -
Ohtomi Taku,
Higashi Sayuri L.,
Mori Daisuke,
Shibata Aya,
Kitamura Yoshiaki,
Ikeda Masato
Publication year - 2021
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24200
Subject(s) - dipeptide , side chain , self assembly , chemistry , morphology (biology) , phenylalanine , group (periodic table) , stereochemistry , nanotechnology , peptide , organic chemistry , materials science , amino acid , polymer , biochemistry , biology , genetics
We report self‐assembled nanostructures of dipeptides hydrazides, in which alanine and/or phenylalanine are employed as components to investigate the effect of the side chain phenyl group on the morphology of self‐assembled nanostructures. We demonstrated that the dimensions of the self‐assembled nanostructures can vary from 1D (fiber and tubular) to 2D (sheet) solely by adjusting the position of the side chain phenyl group in the simple molecular scaffold of the dipeptide hydrazides. This study highlights the significance and potential of systematic investigations for fine‐tuning the morphology of aqueous self‐assembled structures of the dipeptide hydrazides with the aim of exploring functional soft nanomaterials.