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Designing stapled peptides to inhibit protein‐protein interactions: An analysis of successes in a rapidly changing field
Author(s) -
Bluntzer Marie T. J.,
O'Connell James,
Baker Terry S.,
Michel Julien,
Hulme Alison N.
Publication year - 2021
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24191
Subject(s) - peptide , computational biology , drug discovery , field (mathematics) , computer science , nanotechnology , bioinformatics , chemistry , biology , biochemistry , materials science , mathematics , pure mathematics
Two decades after their discovery, stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads. Research groups across the world are testing innovative methodologies for their design, with dozens of publications released every month. A number of stapled peptide drug candidates have recently entered clinical trials. In this review, we provide an overview of successful methods for their construction, highlight trends in the deposited crystal structures of stapled peptide complexed to their targets and discuss properties that contribute towards improved pharmacological profiles.