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Cover Image, Volume 112, Issue 3
Publication year - 2020
Publication title -
peptide science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24174
Subject(s) - linker , peptide , cover (algebra) , receptor , g protein coupled receptor , computational biology , peptide library , computer science , chemistry , cancer research , biochemistry , medicine , biology , peptide sequence , programming language , mechanical engineering , gene , engineering
Worm et al . review recent developments in targeted cancer therapy. Peptide‐binding G protein‐coupled receptors (GPCRs) overexpressed in cancerous tissue can be addressed by peptide ligands, which in turn can serve as tumour‐selective carriers for use in peptide‐drug conjugates (PDCs). PDCs contain the peptide coupled to a smart linker that facilitates the controlled release of the attached drug. The drug can be a specific toxophore, radiolabel or boron‐10 for boron neutron capture therapy. The receptor‐PDC complex selectively binds to the cells that overexpress the targeted GPCR and is internalised, thus facilitating the drug to enter tumour cells while sparing healthy tissue. (doi: 10.1002/pep2.24171 )