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Bent into shape: Folded peptides to mimic protein structure and modulate protein function
Author(s) -
Merritt Haley I.,
Sawyer Nicholas,
Arora Paramjit S.
Publication year - 2020
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24145
Subject(s) - protein folding , protein tertiary structure , protein structure , folding (dsp implementation) , coiled coil , protein secondary structure , biophysics , beta sheet , chemistry , helix (gastropod) , biology , biochemistry , engineering , ecology , snail , electrical engineering
Protein secondary and tertiary structure mimics have served as model systems to probe biophysical parameters that guide protein folding and as attractive reagents to modulate protein interactions. Here, we review contemporary methods to reproduce loop, helix, sheet, and coiled‐coil conformations in short peptides.