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Publication year - 2018
Publication title -
peptide science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24106
Subject(s) - cover (algebra) , peptide , sea anemone , disulfide bond , citation , computer science , image (mathematics) , combinatorics , chemistry , stereochemistry , information retrieval , computational biology , biochemistry , biology , world wide web , artificial intelligence , mathematics , ecology , mechanical engineering , engineering
OspTx2a is a new potassium channel (K V )‐blocking peptide, identified from a transcriptomic and proteomic study of the sea anemone Oulactis sp. It belongs to the ShKT superfamily of peptides and proteins. Norton and co‐workers report the solid phase synthesis of OspTx2a. The synthetic peptide gave two peaks on HPLC, which had identical masses, the same disulfide bond connectivities, and very similar solution structures. NMR chemical shift and structural analyses suggest that the second species contains D ‐Cys at the C‐terminus rather than L ‐Cys. Both peptides show activity against K V 1 channels. (doi: 10.1002/pep2.24073 )