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Bridged bicyclic peptides: Structure and function
Author(s) -
Thombare Varsha J.,
Hutton Craig A.
Publication year - 2018
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24057
Subject(s) - bicyclic molecule , peptide , protease , chemistry , stereochemistry , function (biology) , computational biology , combinatorial chemistry , biochemistry , biology , enzyme , microbiology and biotechnology
Abstract Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides has great potential for the development of novel peptide therapeutics and molecular probes. In this review, we highlight the structural complexity, synthesis/biosynthesis, and biological applications of bridged bicyclic peptides.