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F rom self‐assembled peptide‐ynes to peptide polyacetylenes and polydiacetylenes
Author(s) -
Marafon Giulia,
Motta Maria Angela,
Toniolo Claudio,
Moretto Alessandro
Publication year - 2018
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 7
ISSN - 2475-8817
DOI - 10.1002/pep2.24036
Subject(s) - polydiacetylenes , monomer , moiety , polymerization , tetrapeptide , chemistry , peptide , polymer , intermolecular force , covalent bond , polymer chemistry , self assembly , combinatorial chemistry , organic chemistry , molecule , biochemistry
A set of four organogelators from an α‐amino acid derivative to a tetrapeptide, covalently linked to an acetylenic moiety, was studied in terms of polymerization efficiencies to afford peptide polyacetylenes and polydiacetylenes. Peptides were designed to improve the organogelator behavior via formation of intermolecular H‐bonding‐mediated β‐sheet networks as a function of their main‐chain length. The polymerization experiments were run under appropriate conditions for the various monomers with the aim at elucidating how the monomer self‐assembly process might influence polymer formation. Starting compounds and their corresponding polymers were characterized by a variety of spectroscopic and microscopic techniques.